Témavezetés adatlap
Gayatri Gayatri
hallgató
témavezetés címe
Pharmaceutical analysis using capillary electrophoresis
intézmény
doktori iskola
témavezető
témavezetés módja
egyéni
fokozat típusa
PhD
témavezetés leírása
: The several methods of capillary electrophoresis (CZE, MEKC, CGE, CITP, CIEF, CEC) are very effective for analysis of pharmaceuticals. Small inorganic, large organic compounds or very large proteins (monoclonal antibodies) can be analyzed. In our lab, for the detection of the separated components on-capillary UV/Vis, LED induced fluorescent, capacitavly coupled contactless conductivity or ESI-qTOF-MS can be used. This instrumental background makes possible to carry out solution stability study or the in-vivo/in-vitro metabolism of the pharmaceuticals and to perform qualitative/quantitative analysis in clinical samples. For the LEDIF detection the derivatization of the analyte component should be optimized. We intend to utilize the great advantages of capillary electrophoresis as direct introduction of samples with even high salt/protein content into the separation capillary without remarkable interferences or the necessity of minimal sample consumption for the analysis. The planned research joins to our microfluidic work (fabrication of microchips, electrophoretic separation in microfluidic channel systems, developing special detection for microchips, interfacing between microchips and electrospray mass spectrometer).
képzés kezdete
2022-09-01
abszolutórium megszerzésének várható ideje
2026-08-01
státusz
folyamatban lévő
témakiírás
témakiírás címe