Témakiírások
Synthesis of potential TRADD/TRAF2 and cFLIP inhibitors
témakiírás címe
Synthesis of potential TRADD/TRAF2 and cFLIP inhibitors
témakiíró
témakiírás leírása
"Apoptosis is a programmed cell death that multicellular organisms use under various circumstances to remove unwanted or damaged cells. In the immune system, immune cells play a crucial role in removing damaged or potentially dangerous cells. If these abnormal cells are not removed, they can develop into tumors. In addition, once the immune response is complete, activated immune cells must be removed to resolve inflammation and restore homeostasis. Failure to remove activated immune cells can lead to tissue damage and the development of autoimmune diseases.
To address these challenges, this project aims to identify and develop novel small-molecule inhibitors (SMIs) that sensitize tumor cells for efficient removal. A promising approach involves targeting the interaction between the TRADD-TRAF2 protein complex, and the cFLIP protein. Recent studies suggest that disrupting the TRAF2/5 docking site of TRADD (TNFR1-associated death domain protein) is a viable strategy for disrupting this interaction.
In cooperation, in silico approaches will be applied to design and develop novel TRADD–TRAF2 and cFLIP inhibitors, which are expected to promote apoptotic signaling over the non-canonical death receptor (DR) pathway. Following the evaluation of their synthetic accessibility, the synthesis of promising candidates will be planned by retrosynthetic analysis and carried out using innovative synthetic methods such as microwave-assisted synthesis and flow chemistry. The biological activity and toxicity of the identified compounds will be assessed in vitro on tumor and immune cell models, in collaboration with partner laboratories."
To address these challenges, this project aims to identify and develop novel small-molecule inhibitors (SMIs) that sensitize tumor cells for efficient removal. A promising approach involves targeting the interaction between the TRADD-TRAF2 protein complex, and the cFLIP protein. Recent studies suggest that disrupting the TRAF2/5 docking site of TRADD (TNFR1-associated death domain protein) is a viable strategy for disrupting this interaction.
In cooperation, in silico approaches will be applied to design and develop novel TRADD–TRAF2 and cFLIP inhibitors, which are expected to promote apoptotic signaling over the non-canonical death receptor (DR) pathway. Following the evaluation of their synthetic accessibility, the synthesis of promising candidates will be planned by retrosynthetic analysis and carried out using innovative synthetic methods such as microwave-assisted synthesis and flow chemistry. The biological activity and toxicity of the identified compounds will be assessed in vitro on tumor and immune cell models, in collaboration with partner laboratories."
felvehető hallgatók száma
1 fő
helyszín
BME Szerves Kémia és Technológia Tanszék
jelentkezési határidő
2025-12-07