Témakiírások
Biomimetic flow chemistry-based drug metabolite identification and synthesis
témakiírás címe
Biomimetic flow chemistry-based drug metabolite identification and synthesis
témakiíró
témakiírás leírása
The PhD research focuses on the development of scalable flow chemistry-based methods for drug metabolite identification and synthesis. The background of this study is that biomimetic catalysts such as synthetic metalloporphyrins are able to imitate the oxidative metabolism in human liver by cytochrome P450 isoenzymes. The immobilization of metalloprophyrins to solid carriers can provide biomimetic catalyst system with enhanced stability and efficiency. The supported catalysts can be applied as a stable filling material on packed bed reactors as well. The optimization opportunities of biomimetic oxidation (such as oxidizing agents, solvent mixtures, residence time etc.) will be also investigated in batch and flow-chemistry mode as well. The biomimetic reactions will be followed by LC-DAD-(MS), HR-MS and NMR spectroscopy. The results of these research can support the early stage drug discovery and the synthesis of various API metabolites at analytical and preparative scale.
The announced topic provides an opportunity as a cooperative PhD program (KDP), where potential industry partners could be EGIS, Servier, ThalesNano, Solvo and Waters Research Center.
The announced topic provides an opportunity as a cooperative PhD program (KDP), where potential industry partners could be EGIS, Servier, ThalesNano, Solvo and Waters Research Center.
felvehető hallgatók száma
1 fő
helyszín
BME Kémiai és Környezeti Folyamatmérnöki Tanszék
jelentkezési határidő
2025-12-07