Témakiírások
Mechanistic understanding of transcriptional regulation of heat stress response in Brassicaceae
témakiírás címe
Mechanistic understanding of transcriptional regulation of heat stress response in Brassicaceae
intézmény
doktori iskola
témakiíró
tudományág
témakiírás leírása
"Climate change negatively affects the yield of crops worldwide. Rapeseed (Brassica napus) is an important agricultural crop. The valuable product of B. napus is the rapeseed oil, an important source of edible oil. Rapeseed is sensitive to heat in all stages of development. As research on crops is very laborious, the knowledge on basic cellular pathways like transcription and heat stress response is limited.
Transcriptional regulation is a central molecular pathway that coordinates developmental changes and adaptation to environmental stresses at cellular level. Although heat stress transcriptomes were extensively studied, how the players of transcriptional machinery themselves are regulated is largely unknown.
In the present programme we propose to uncover the mechanisms coordinating the transcriptional process under ambient and heat stress conditions in the model plant Arabidopsis thaliana and its relative crop plant Brassica napus. Specific aims of our project are to (i) study the requirement of the RNA polymerase subunit 9 (RPB9) during heat stress adaptation, (ii) understand the mechanism of polymerase II elongation factor TFIIS’s and RPB9’s action in regulation of transcriptional fidelity, and (iii) uncover the genetic and molecular interaction between nuclear and cytoplasmic transcriptional- and protein-quality control pathways. We hope that our findings will significantly contribute to basic understanding of transcriptional regulation and will accelerate the development of heat-tolerant plants that may have a huge importance in the light of climate change."
Transcriptional regulation is a central molecular pathway that coordinates developmental changes and adaptation to environmental stresses at cellular level. Although heat stress transcriptomes were extensively studied, how the players of transcriptional machinery themselves are regulated is largely unknown.
In the present programme we propose to uncover the mechanisms coordinating the transcriptional process under ambient and heat stress conditions in the model plant Arabidopsis thaliana and its relative crop plant Brassica napus. Specific aims of our project are to (i) study the requirement of the RNA polymerase subunit 9 (RPB9) during heat stress adaptation, (ii) understand the mechanism of polymerase II elongation factor TFIIS’s and RPB9’s action in regulation of transcriptional fidelity, and (iii) uncover the genetic and molecular interaction between nuclear and cytoplasmic transcriptional- and protein-quality control pathways. We hope that our findings will significantly contribute to basic understanding of transcriptional regulation and will accelerate the development of heat-tolerant plants that may have a huge importance in the light of climate change."
felvehető hallgatók száma
1 fő
helyszín
MATE, GBI, Gödöllő
jelentkezési határidő
2026-05-31