Generation and analysis of dynamic protein structural ensembles based on NMR data

Eötvös Loránd Tudományegyetem

Hevesy György Kémia Doktori Iskola

Gáspári Zoltán

Bodor Andrea

kémiai tudományok

Protein NMR is the most powerful method to characterize protein internal dynamics at an atomic level and at multiple time scales. The obtained NMR parameters can be used to generate atomic-level structural models of proteins in order to explore the exnetnt and biological relevance of specific dynamical features. These approaches rely on ensemble-based representations rather than single structural models. The proposed research focuses on the generation and anaylsis of such models based on measurements performed at ELTE on various proteins.

1 fő

"Eötvös Loránd University, Institute of Chemistry, Budapest, Hungary Pázmány Péter Cathlic University, Faculy of Information Technology & Bionics, Budapest, Hungary"

2016-05-31

English

Basic knowledge of protein structure is required. Familiarity with Linux, programming in C/C++/Perl/Python/Java and with NMR-based protein structure determination is a plus.