Thesis supervisor: Margit Szentesi
Web address (URL): http://doktoriiskola.etk.pte.hu/ Location of studies (in Hungarian): Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary Abbreviation of location of studies: EDI
Description of the research topic:
The effectiveness of radiosynoviorthesis in chronic synovitis of rheumatoid arthritis.
Rheumatoid arthritis is a chronic progressive disease affecting 1% of the population. It deteriorates the patients' quality of life and shortens their lifespan by 5-10 years. The essence of the disease lies in chronic synovitis. If synovitis is not eliminated, the synovium spreads onto the cartilage and destroys it. The main medications for the disease include base therapy, biological treatments, and locally administered radiosynoviorthesis, during which the grape-like proliferating thick synovial membrane perishes, giving rise to a thin, fibrotic new membrane that does not produce fluid and does not damage the cartilage.
Objectives of the study:
The aim of the PhD thesis is partly to analyze and process retrospective studies conducted over the past 20 years on the effectiveness of radiosynoviorthesis, as well as ongoing prospective studies, in line with the following objectives:
Comparison of short-term and long-term results of Y-90 radiosynoviorthesis in rheumatoid arthritis (RA).
Examination of the relationship between objective and subjective scoring systems and total scores.
Investigation of the correlation between patients' age, gender, and the effectiveness of radiosynoviorthesis in RA.
Exploration of the relationship between the duration of synovitis and the effectiveness of radiosynoviorthesis in RA.
Analysis of the correlation between the number of knee punctures before radiosynoviorthesis and its effectiveness in RA.
Investigation of the correlation between the number of intra-articular steroid injections before radiosynoviorthesis and its effectiveness in RA.
Correlation between Steinbrocker stage of RA patients and the outcome of radiosynoviorthesis.
Relationship between the local radiographic stage of the knee joint and the outcome of radiosynoviorthesis in rheumatoid arthritis.
Correlation between the activity of rheumatoid arthritis and the effectiveness of radiosynoviorthesis.
Relationship between local knee joint activity (Tc index) and the effectiveness of radiosynoviorthesis.
Connection between effective base therapy and the effectiveness of radiosynoviorthesis in rheumatoid arthritis.
Relationship between steroid therapy and the effectiveness of radiosynoviorthesis in rheumatoid arthritis.
Correlation between immunological parameters and the effectiveness of radiosynoviorthesis.
Impact of local radiographic stage on effectiveness.
Relationship between surgeries performed before radiosynoviorthesis and its effectiveness in RA.
Examination of the correlation between the number of knee punctures after radiosynoviorthesis and its effectiveness in RA.
Analysis of the relationship between the number of intra-articular steroid injections after Y-90 radiosynoviorthesis and its effectiveness.
Required language skills: English language exam B2 level Number of students who can be accepted: 1
Deadline for application: 2024-05-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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