Acute lymphoblastic leukemia (ALL) is the most frequent malignancy in childhood. The optimal therapeutical decision-making devoid of under- or overtreatments relies on the international classification of the disease and is based on the presence or absence of various specific, non-random genetic aberrations. The two most common subtypes are defined by the ETV6/RUNX1 translocation and hyperdiploidity with 51-66 modal chromosome number making up altogether appr. 55% of all pediatric ALL (pALL) and appr. 80% of patients between 2 and 7 years of age. The goal of this study is the identification of the 4 or 5 chromosomal abnormalities most important for the diagnosis and treatment of hyperdiploid all arising presumably in utero. The fluorescence in situ hybridization performed on non-dividing, interphase cells (i-FISH) and the automated evaluation of i-FISH signals are the most efficient approaches to identify these chromosomal aberrations and clonal evolution processes. The investigation of large number of samples archived in the Department of Pathology forms the basis of this study.
felvehető hallgatók száma: 1
Jelentkezési határidő: 2024-05-16
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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