Thesis supervisor: Eszter Hegyi
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12. Abbreviation of location of studies: ÁOK
Description of the research topic:
Chronic pancreatitis (CP) is a progressive inflammatory disease of the pancreas leading to irreversible morphological changes and impairment of both exocrine and endocrine functions. There is no specific therapy for CP and the cost of lifelong supporting care places a significant burden on the health care systems worldwide. CP is a complex chronic inflammatory disorder which results from the interplay of genetic predisposition, environmental exposures and random stressful events. The major etiologic factor of CP in adults is excessive alcohol consumption, however growing evidence suggests a substantial contribution of genetic predisposition to pancreatitis, especially at younger age. Over the past 20 years the role of genetic factors in the etiology of CP has been extensively studied and a mechanistic model which posits that uncontrolled intrapancreatic trypsin activity is responsible for the disease onset and progression has been established. More recently, an alternative pathological pathway of pancreatitis risk unrelated to accelerated intrapancreatic trypsinogen activation that involves endoplasmic reticulum stress caused by mutation-induced misfolding of digestive enzymes has been identified. Our aim is to investigate how high-fat diet/smoking and genetic risk synergize in the development of CP. This translational approach will contribute to gain better understanding of the importance of gene-environment interactions in the pathogenesis of chronic pancreatitis.
Number of students who can be accepted: 1
Deadline for application: 2024-05-16
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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