Thesis supervisor: Imre Miklós Boros
co-supervisor: László Henn
Location of studies (in Hungarian): University of Szeged, Dept. Biochemistry and Molecular Biology and Biological Research Centre , Institute of Biochemistry Abbreviation of location of studies: SzTE
Description of the research topic:
Epigenetic effects which are not encoded by the nucleotide sequence of DNA determine the diverse cellular and tissue functions of an organism despite that it’s cells are equal in their genetic content. The major components of the epigenetic factors are the posttranslational modifications of nucleosomal histones and the usage of alternative histone variants. The major aim of the project is to uncover new mechanisms by which specific histone modifications – fe. ubiquitylation – and specific alternative histone forms – fe.H4var, H1 var – contribute to the maintenance of cellular functions in differentiated cells, for example in neurones.
The experimental approches involve parallel use of genetic, biochemistry and cell biology techniques in a combination of the most advanced methods on chromatin biology. Drosophila will be one, but not the exclusive experimental modell used.
Required language skills: English Number of students who can be accepted: 2
Deadline for application: 2023-06-01
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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