ODT - THESIS TOPIC: István Wittmann: The effect of oxidative ...


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Thesis topic proposal

The effect of oxidative stress on the efficacy of insulin and erythropoietin

THESIS TOPIC PROPOSAL

Institute: University of Pécs
clinical medicine
Doctoral School of Clinical Medicine

Thesis supervisor: István Wittmann
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

We plan the investigation of following hypotheses:
1. Phosphorylation of eNOS changes upon cigarette smoke in 3T3-L1 adipocytes. Western blot studies. 2. Examination of phosphorylation of Akt using Western blot in 3T3-L1 adipocytes due to oxidative stress. 3. Examination of phosphorylation of Erk in 3T3-L1 adipocytes due to oxidative stress using Western blot. 4. To study the effect of antioxidant resveratrol on the signaling pathways of insulin and erythropoietin using Western blot. 5. To study the connection between carbohydrate metabolism and oxidative stress using continuous interstitial glucose monitoring (CGMS) and measurement of oxidative stress. 6. Measurement of hydrogen-peroxide in vivo with a sensor in development.

Number of students who can be accepted: 1

Deadline for application: 2023-05-19

2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).