Thesis topic proposal
András Komócsi
Investigation of clinical and genetical factors influencing residual platelet reactivity after coronary stent implantation. An individualised antiplatelet strategy


Institute: University of Pécs
clinical medicine
Doctoral School of Clinical Medicine

Thesis supervisor: András Komócsi
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

Dual antiplatelet therapy (AT) is essential in preventing recurrent thrombotic events after coronary interventions. However, substantial interindividual differences were described in the degree of residual platelet reactivity (RPR) despite aspirin and clopidogrel administration. High RPR is an independent predictor of death, myocardial infarction and stent thrombosis after PCI; thus, optimized AT in high-risk patients would be of great importance. We aim to establish a diagnostic system involving genetic and clinical parameters that predicts and monitors AT efficacy. With identification and better insight into the underlying mechanisms we aim to set up a tailored AT algorithm for patient with high RPR.

Number of students who can be accepted: 1

Deadline for application: 2023-05-19

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