ODT - THESIS TOPIC: Ágnes Mária Sonnevend: Contribution of mobile genetic ...


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Thesis topic proposal

Contribution of mobile genetic elements in the development of multi-drug resistance in Gram negative bacilli

THESIS TOPIC PROPOSAL

Institute: University of Pécs
theoretical medicine
Doctoral School of Basic Medicine

Thesis supervisor: Ágnes Mária Sonnevend
Location of studies (in Hungarian): PTE ÁOK
Abbreviation of location of studies: ÁOK

Description of the research topic:

Antimicrobial resistance (AMR) poses a significant threat to human health worldwide. Resistance of Gram-negative bacilli to carbapenem and third generation cephalosporin antibiotics is ranked as critical priority for research by the World Health Organisation. Resistance to these antibiotics is often conferred by genes located on mobile genetic elements, e.g., plasmids or transposons. We aim to study human and animal isolates of Gram-negative bacilli with such resistance phenotype to map mobile genetic elements carrying carbapenem and 3rd generation cephalosporin resistance genes. We also would like to assess what other resistance determinants (antibiotic, disinfectant or heavy metal) are co-located on these mobile genetic elements, which may promote their spread.

Number of students who can be accepted: 1

Deadline for application: 2023-05-19

2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).