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Thesis topic proposal
 
Margit Solymár
Possible therapeutic targets in obesity: neurohormonal, metabolic, and vascular changes

THESIS TOPIC PROPOSAL

Institute: University of Pécs
theoretical medicine
Doctoral School of Pharmacologycal and Pharmaceutical Sciences

Thesis supervisor: Margit Solymár
Location of studies (in Hungarian): PTE ÁOK
Abbreviation of location of studies: ÁOK


Description of the research topic:

The epidemic of obesity is one of Europe’s most serious public health challenges: more than half of the adults are overweight or obese. If the current trend continues, by 2022, more children and adolescents will be obese than moderately or severely malnourished. As a result of obesity, the amount and composition of adipokines and cytokines released from perivascular adipose tissue change, which is associated with endothelial injury and a decrease in endothelium-dependent vasorelaxation. Obesity leads to metabolic disorders that may play a central role in the development of insulin resistance, type 2 diabetes, and increased vascular resistance. Finding neurohormonal mechanisms of abnormal body weight regulation underlying obesity is key to identifying new therapeutic targets. Our question is whether the metabolic and concomitant endothelial impairments due to obesity can be repaired or reversed.

Number of students who can be accepted: 1

Deadline for application: 2023-05-17


2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).

 
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