Thesis supervisor: Rita Sinka
Location of studies (in Hungarian): University of Szeged Faculty of Science and Informatics, Institute of Biology, Department of Genetics Abbreviation of location of studies: SzTE
Description of the research topic:
The mechanisms of spermatogenesis are conserved to varying extents across many species, in particular the fruit fly Drosophila melanogaster. The high degree of human disease recapitulation, ease of acquiring specimens from selected developmental stages, as well as the sophistication of genetic, biochemical manipulations and imaging amenability of fixed or living specimens have made Drosophila a powerful, well-established system for studying spermatogenesis. During germ cell formation we can investigate the function of centrosomes, basal body, mitochondria and cilia formation but also suitable to investigate the composition of specialized protein complexes, such as sperm proteasomes. We can follow the dynamic changes, regulation of organelle assembly, and their functions during sperm development. The diversity of microtubule-organizing centers (MTOC) in terms of their compositions, subcellular localizations, the mechanisms of microtubule assembly, and the biological functions they support are beginning to come into focus in recent years. In the PhD projects, we aim to reveal the molecular composition and function of the newly identified testis-specific MTOCs, their interacting proteins and also the subcellular localization of them in post-meiotic stages. Based on our published and preliminary data we aim to study the composition, distribution and potential interacting partners of sperm proteasome in Drosophila. Hence, the molecular and cellular mechanisms uncovered by the study of Drosophila spermiogenesis will enhance our understanding of similar processes crucial to cellular remodelling and human male fertility.
Required language skills: English Recommended language skills (in Hungarian): English Further requirements: We are looking for a highly motivated student with experience in molecular biology and biochemistry. We expect the candidate to read scientific literature and discuss scientific problems.
Number of students who can be accepted: 2
Deadline for application: 2021-09-01
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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