Thesis supervisor: Péter Burkovics
Location of studies (in Hungarian): ELKH, Biological Research Center Abbreviation of location of studies: SZBK
Description of the research topic:
The accurate replication of special DNA structures, namely the G-quadruplexes (G4) is essential for the cells because its failure results in oncogene activation or cancer formation. Replication of G4 structures is likely a two-step process: first, a DNA helicase unwinds the stable G4 structure and second, the replication machinery replicates it.
The first wave of G4 replication research described several DNA helicases with G4 unwinding activity in vitro. Surprisingly the analysis of deletion strains showed that only a few of them show G4 replication failure. In yeast the deletion of pifl gene has strong phenotype. Although in humans Pifl is also present, the FancJ is known as the major G4 unwinding helicase. Our central hypothesis is that during replication the action of DNA helicases is tightly regulated and coordinated with the replication machinery at G4 sites. Our major question is: How does this regulatory mechanism work?
Required language skills: English Recommended language skills (in Hungarian): English Number of students who can be accepted: 4
Deadline for application: 2021-09-01
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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