Thesis topic proposal
Attila Hunyadi
Studies on bioactive ecdysteroid derivatives


Institute: University of Szeged
Doctoral School of Pharmaceutical Sciences

Thesis supervisor: Attila Hunyadi
Location of studies (in Hungarian): Szeged
Abbreviation of location of studies: SZTE

Description of the research topic:

Ecdysteroids are herbal analogs of the insect molting hormone, with a complex defensive role against pests. These compounds are, however, known to exert several beneficial (general strengthening, anabolic, adaptogenic, etc.) effects through a non-hormonal, partly understood mechanism in mammals, based on which ecdysteroid-containing food supplements are worldwide available. Moreover, our research group discovered the strong sensitizing activity of certain (mostly semi-synthetic) derivatives on resistant tumor cells. The PhD topic is connected to a complex multidisciplinary research program on the above aspects of these compounds, and it involves their preparation from natural sources, various semi-synthetic modifications, and analyzing the structure-activity relationships. The work involves intensive international collaboration, hence good English language skills are a must.

Required language skills: fluent english
Recommended language skills (in Hungarian): fluent english
Number of students who can be accepted: 1

Deadline for application: 2021-05-01

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