Thesis supervisor: Péter Horváth
Location of studies (in Hungarian): BIOMAG lab, Synthetic and systems biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences Abbreviation of location of studies: SzBK
Description of the research topic:
In this work the Candidate will develop and coordinate the steps of a 3D high content screening system. The system includes spheroid and organoid (oid) generation, a pre-selection process to prepare oids with uniform properties for microscopy; the automated imaging using high-end confocal and light sheet microscopes available at our labs in Szeged and Helsinki, the image analysis at single cell level and finally phenotypic analysis to determine the cellular composition of the 3D cell aggregates. The pre-selection and image analysis sub-systems are already under development in the BIOMAG lab, the Candidate will harmonize their work and insertion into the pipeline. Based on our collaboration with the Children's Hospital in Heidelberg and the largest pediatric brain tumor research centers in the World, we will apply the developed system to propose personalized precision treatments for childhood brain tumors.
Required language skills: English Number of students who can be accepted: 1
Deadline for application: 2019-12-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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