Thesis supervisor: László Kredics
co-supervisor: András Szekeres
Location of studies (in Hungarian): Department of Microbiology, Faculty of Science and Informatics, University of Szeged Abbreviation of location of studies: SZTE
Description of the research topic:
Filamentous fungi are capable of producing numerous secondary metabolites, including peptides produced by non-ribosomal biosynthesis. A group of such metabolites is comprised of peptaibols, which are linear, characteristically 6-20 amino acid long amphipatic, biologically active oligopeptides. Due to their amphipatic nature and antibiotic properties they are able to form voltage-dependent ion channels in biological membranes and to inhibit the cell wall synthesis of competitor fungi. They may also aid plant protection against phytopathogenic fungi by inducing systemic resistance in plants. The topic covers the quantitative and qualitative analysis of peptaibol profiles produced by filamentous fungi from the genus Trichoderma with the aid of HPLC-MS technique, the primary and secondary structure elucidation of particular peptaibol compounds, as well as the investigation of their biological actvities towards test microbes and higher model organisms.
Required language skills: English Further requirements: experience as coauthor and oral presenter in the presentation of conference materials
Number of students who can be accepted: 1
Deadline for application: 2019-12-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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