Thesis supervisor: Györgyi Ferenc
Location of studies (in Hungarian): HAS Biological Research Centre, Szeged, Institute of Plant Biology Abbreviation of location of studies: SzBK
Description of the research topic:
Recombinant DNA technology opened new possibilities in plant breeding. At the beginning, alterations of the plant genome and acquisition of new traits were achieved by the introduction of transgenes. A drawback of this method is the random integration of the transgenes into the genome. Thus, the development of techniques allowing targeted modification of the function of selected genes became necessary. The goal of our research is the development of methods using chemically modified oligonucleotides to achieve the desired genetic or epigenetic changes. The purpose of chemical modifications is to increase binding specificity and in vivo stability of the oligonucleotide.
A growing body of data suggest that the expression of genes can be influenced by changing their epigenetic characteristics such as the pattern of DNA methylation. One of our research goals is to explore the possibilities of using modified oligonucleotides to increase the specificity of targeted DNA methylation.
Required language skills: English Number of students who can be accepted: 1
Deadline for application: 2019-12-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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