Thesis topic proposal
Mechanisms of drug-induced proarrhythmic adverse effects


Institute: University of Szeged
theoretical medicine
Doctoral School of Multidisciplinary Medical Scienses

Thesis supervisor: István Baczkó
Web address (URL): http://web.med.u-szeged.hu/phcol/index_a.htm
Location of studies (in Hungarian): Department of Pharmacology and Pharmacotherapy, Faculty of Medicine
Abbreviation of location of studies: SZTE

Description of the research topic:

Preclinical drug safety tests employ healthy animals and animal tissues for the assessment of the cardiac repolarization prolonging effects of compounds, however, these tests do not represent patients exhibiting increased arrhythmia susceptibility, and clinical and animal studies have shown that the degree of repolarization prolongation does not correlate directly with the incidence of arrhythmias. Therefore, the reliable prediction of proarrhythmic potency of compounds in development is lacking.
In this program, the student gains insight into cardiac electrophysiology, with special attention paid to ventricular repolarization and repolarization reserve, as well as mechanisms of sudden cardiac death. The candidate will master in vitro and in vivo experimental techniques in cardiac electrophysiology and contributes to the identification of novel biomarkers for the improved assessment of proarrhythmic adverse effects of drugs and to mechanisms and management of arrhythmias in different pathological settings.

Required language skills: English B2
Further requirements: 
TDK munka

Number of students who can be accepted: 1

Deadline for application: 2019-08-31

All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )