Thesis supervisor: Zsuzsanna Hamari
Location of studies (in Hungarian): University of Szeged, Faculty of Science and Informatics, Department of Microbiology Abbreviation of location of studies: SZTE
Description of the research topic:
Physiological role of HmbA, HmbB and HmbC HMGB proteins (high mobility group-box domain containing chromatin associated linker proteins) of Aspergillus nidulans. Implementation of the project involves the construction and study of gene deletion mutants (studies of morphology, carbon- and nitrogen-source utilization, temperature-, pH- and oxidative stress-tolerance, asexual and sexual reproduction, secondary metabolism), localization of GFP-fused HMGB proteins, complementation studies in deletion yeast strains by heterologous expression of A. nidulans HMGB genes. PhD students will acquire skills in wide range of molecular biological techniques as well as in classic genetics.
Karácsony Z, Gácser A, Vágvölgyi C, Scazzocchio C, Hamari Z. (2014) A dually located multi-HMG-box protein of Aspergillus nidulans has a crucial role in conidial and ascospore germination.Mol Microbiol. 2014 Oct;94(2):383-402.
Karácsony Z, Gácser A, Vágvölgyi C, Hamari Z. (2015) Further characterisation of the role of the mitochondrial HMG-Box protein in the intracellular redox environment of Aspergillus nidulans. Microbiology. 2015 Oct;161(10):1897-908.
Required language skills: English Further requirements: basic microbiological and molecular biological skills
Number of students who can be accepted: 1
Deadline for application: 2019-08-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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