Thesis topic proposal
The role of mucin in the pathomechanism of pancreatic cancer


Institute: University of Szeged
theoretical medicine
Theoretical Medicine Doctoral School

Thesis supervisor: Viktória Venglovecz
Location of studies (in Hungarian): SZTE ÁOK Farmaológiai és Farmakoterápiai Intézet
Abbreviation of location of studies: FFI

Description of the research topic:

Pancreatic cancer (PC) is the fourth leading cause of cancer death and accounts for 7% of all cancer death. Notably,70% of PC occurs in the head of the pancreas which reaching a critical size and can blocks the main pancreatic duct and the common bile duct, thus increasing the concentration of bile acids (BAs) in the serum. It is hypothesized that levels of BA’s increases the tumorgenic potential of PC cells by changing the expression of oncogenic mucins. MUC4 is a transmembrane glycoprotein that is overexpressed in pancreatic ductal adenocarcinoma (PDAC) but never in the normal pancreatic tissues. Our aim was to study the effect of various bile acids on mucin expression and tumor progression.

Required language skills: english
Number of students who can be accepted: 1

Deadline for application: 2019-06-30

All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )