Thesis supervisor: Tamás Cserni
Location of studies (in Hungarian): Univ. Szeged, Fac. of Medicine, Institute of Surgical Research Abbreviation of location of studies: SZTE
Description of the research topic:
Recently we invented a new technique, the Spiral Intestinal Lengthening and Tailoring (SILT), which is a relatively easy procedure, less risky and results in more physiological lengthened bowel compared to present techniques in short bowel syndrome. The technique already has been applied in the clinical practice with initial success. Our research focuses on the motility of the lengthened bowel after different procedures, invention of an artificial sphincter, which will be able to facilitate intestinal tissue expansion before intestinal lengthening and reconstruction of the ileocaecal sphincter.
The Structured Bowel Expansion combined with the Autologue Intestinal Reconstructive Surgery (AIRS) provides new promising alternative of intestinal transplantation in severe short bowel syndrome. It is based on the fact that the short bowel is able to adapt and increase absorptive surface and this can be enhanced by mechanical force. The adapted and expanded bowel loses its motility, but it can be restored with bowel lengthening and tailoring. At present the Bianchi’s longitudinal intestinal lengthening and tailoring (LILT) and the serial transverse enteroplasty (STEP) procedures have gained popularity, however both techniques have their own limitations. During the Bianchi’s procedure the mesentery has to be split, which is surgically quite challenging and may compromise blood supply. It can only tailor the diameter to half and double the length of the dilated adapted intestine. The STEP procedure is easy, more adjustable, but changes to orientation of the muscle fibres of the intestine making the circular, longitudinal and the longitudinal, circular. Its effect to the intestinal motility is still unclear. Recently we invented a new technique, the Spiral Intestinal Lengthening and Tailoring (SILT), which is a relatively easy procedure, less risky and results in more physiological lengthened bowel compared to present techniques. The technique already has been applied in human with initial success.
Our research focuses on the following topics of AIRS:
1, Motility of the lengthened bowel after STEP and SILT.
2, Invention of an artificial sphincter providing controlled bowel obstruction / bowel expansion to increase absorptive surface
3, Loss of ileaocaecal valve reduce chance of survival in short bowel state. Recreating a more physiological ileocaecal anastomosis according to our new concept will expectedly popularise the ilecaecal valve replacement. Will increase survival rate and facilitate weaning from total parenteral nutrition.
Required language skills: English Number of students who can be accepted: 1
Deadline for application: 2019-06-15
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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