Thesis topic proposal
Acetylsalicylic acid-tris-hydroxymethyl-aminomethane therapy efficiently reduces colon mucosal damage in a rat model of colitis


Institute: University of Szeged
theoretical medicine
Doctoral School of Multidisciplinary Medical Scienses

Thesis supervisor: Gabriella Varga
Location of studies (in Hungarian): SZTE ÁOK Sebészeti Műtéttani Intézet
Abbreviation of location of studies: SMI

Description of the research topic:

Inflammatory bowel disease (IBD) is accompanied by systemic immune responses with local recruitment of effector cells and the release of cytokines, which collectively enhance the breakdown of the mucosal barrier. In this line, the current strategies to treat IBD are based on immune modulators, anti-inflammatory compounds and the use of anti-cytokine agents, including tumor necrosis factor-α (TNF-α) blockers. Non-steroidal anti-inflammatory drugs (NSAIDs) are also considered useful medication for IBD patients (extraintestinal, musculoskeletal disorders). However, each of these therapies can cause potentially severe side effects (gastritis, gastrointestinal (GI) ulcerative damages). The main goal in our study, to examine the effect of the newly developed acetylsalicylic acid and tris-hydroxymethyl-aminomethane (ASA-Tris) conjugates in rodent model of IBD.

Required language skills: English
Further requirements: 
TDK munka

Number of students who can be accepted: 1

Deadline for application: 2019-08-31

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