Thesis supervisor: Beáta Albert
Location of studies (in Hungarian): Sapientia Hungarian University of Transylvania, Faculty of Csíkszereda Abbreviation of location of studies: SHU
Description of the research topic:
Atherosclerosis is the major risk factor in the development of cardiovascular diseases, particularly coronary artery disease and stroke. Wnts, specifically Wnt5a have been correlated and implicated in atheroslerosis, as well as co-expression of Wnt5a and TRL4 in foam cells and macrophages of human atherosclerotic lesions. The expression of these two proteins probably is induced by oxidized LDL molecules, derived from macrophages. Its activation leads to an intracellular signaling pathway NF-kB and inflammatory citokine production.
This study will focus on fine tuning of co-expression of Wnt5a and TRL4 in macrophages, following the inflammatory markers and proteins in stroke rehabilitation patients. We hypothesise that exersice intervention can inhibit TRL4 signaling and Wnt5a/Fzd5 too.
The cytokine (IL1, IL6, IL8, TNFa) concentration will be assayed from plasma, using specific commercial kits. Proteins (SIRT1, PPARg, FoxO1, FoxO3) will be followed by isolation of mRNA and quantitative RT PCR, before and after exercise intervention. The presumed proteins from TRL4/Pi3K complex will be cloned, expressed and purified, for protein-protein interactions measurments.
Recommended language skills (in Hungarian): English Number of students who can be accepted: 1
Deadline for application: 2018-05-25
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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