Thesis supervisor: László Nagy
Location of studies (in Hungarian): University of Debrecen Abbreviation of location of studies: DEÁOK
Description of the research topic:
Macrophages are very heterogeneous and plastic members of the innate immune system. In the proposed research, we are planning to study the molecular background of alternative macrophage activation-specific functional characteristics using the combination of biochemical, transcriptomic, epigenetic and functional approaches. (1) We would like to examine the potential regulatory role of lipid sensing nuclear receptors including PPARg, RARa and RXRs in the angiogenic and pro-tumoral activity of alternatively activated macrophages. (2) We propose to identify the mechanism and the putative anti-inflammatory role of IL-4/STAT6 signaling-mediated active repression during ex vivo and in vivo alternative macrophage activation. (3) We also plan to study the anti-proliferative and/or pro-apoptotic action of IL-4-induced mir-342-3p during the posttranscriptional regulation of macrophage viability.
Number of students who can be accepted: 1
Deadline for application: 2018-05-15
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
Login
