Thesis supervisor: Katalin Goda
Location of studies (in Hungarian): University of Debrecen, Faculty of Medicine Abbreviation of location of studies: DEÁOK
Description of the research topic:
One of the unresolved problems of cancer as well as of AIDS chemotherapy is the resistance of target tissues against a broad range of compounds applied in the treatment protocols, such as steroids, antineoplastic drugs, immuno-suppressive agents or HIV protease inhibitors. This phenomenon is frequently associated with and caused by the overexpression of certain ABC (ATP Binding Cassette) transporters, including P-glycoprotein (Pgp, MDR1, ABCB1) and breast cancer resistance protein (ABCG2; BCRP), that can actively efflux the chemotherapeutic drugs from the cells leading to a decreased accumulation of drugs in these tissues.
Despite the large body of structural and functional data regarding the ABC transporter proteins, it is still unknown how ATP binding and hydrolysis is coordinated between the two nucleotide binding domains and how drug transport process is coupled to nucleotide binding and hydrolysis. Therefore, the major aim of our project proposal is to study various aspects of these processes in Pgp and ABCG2 utilizing our unique repertoire of biophysical and biochemical tools applicable for systematic examination of the conformation and drug binding affinity changes upon distinct steps of the catalytic cycle.
Number of students who can be accepted: 1
Deadline for application: 2018-05-15
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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