Thesis supervisor: György ifj. Sétáló
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12. Abbreviation of location of studies: ÁOK
Description of the research topic:
Nerve growth facror (NGF)-treated rat pheochromocytoma (PC12) cells stop dividing and, accompanied by process growth, differentiate into a sympathetic neuronal-like phenotype. In the background complex signaling events induce altered gene expression. Extracelllular signal-regulated kinases (ERK1/2) and Src proteins are key elements of this enzymatic regulation. We investigate the phosphorylation and intracellular distribution of these enzymes as a function treatments. Currently we are using NGF or the proteasome inhibitor MG-132 to elicit differentiation.
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