Thesis supervisor: László Nagy
Location of studies (in Hungarian): BRC-HAS, Institute of Biochemistry Abbreviation of location of studies: SZBK
Description of the research topic:
The evolution of multicellularity has been one of the major transitions in the history of life. Although it has been in the focus of interest for a long time, the genetic background of multicellularity remains only partially known. Fungal multicellularity, in addition to having an immense impact on economy and health, has probably been a key factor for the invasion of land also. The aim of the project is to identify the genomic events underlying the evolution of fungal multicellularity and to understand the general principles of the evolution of multicellular life forms. Fungi evolved complex multicellularity in 2 steps: unicellular ancestors first gave rise to filamentous fungi, which later evolved 3-dimensional multicellular fruiting bodies. In our lab, we examine the genetic events (gene duplications, regulatory networks, splicing patterns, etc.) that enabled these two transitions using bioinformatic and transcriptomic approaches. Methods used in the lab include both computational comparative genomic (high-throughput analyses, gene family evolution, phylogenetics and phylogenomics) and wet-lab methods (micro- and molecular biology, transcriptomics, single-cell transcriptomics, laser microdissection, etc.).
Required language skills: English Further requirements: high motivations, team work, good communication skills
Number of students who can be accepted: 3
Deadline for application: 2018-02-28
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
Login
