Thesis supervisor: Péter Galajda
Location of studies (in Hungarian): Biological Research Center, HAS Abbreviation of location of studies: SZBK
Description of the research topic:
Bacteria reproduce by binary fission after which two seemingly identical daughter cells are produced. This mode of reproduction raises several questions. Without a clear distinction between “parents” and “daughters”, can the concept of “age” applied to bacteria? Are the daughter cells really identical/similar (phenotypically)? How does (phenotypic) variability emerge in a clonal bacterial population?
During the project we use a novel experimental platform based on optical trapping and microfluidics to study a growing colony with single cell level of detail for an extended period of time. We track cell elongation and division rate, cell survival, expression levels of proteins and swimming behavior in a constantly dividing population of E. coli bacteria. We expect to see how variability and heterogeneity of these measured parameters develop in a clonal population descended from a single cell.
Required language skills: English Further requirements: University degree and experience in one or more of the following (or related) areas: biology, microbiology, environmental sciences, biophysics, physics, microscopy.
Number of students who can be accepted: 2
Deadline for application: 2018-02-28
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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