témavezető: Csortos Csilla
helyszín (magyar oldal): DE ÁOK Orvosi Vegytani Intézet helyszín rövidítés: DEOVI
A kutatási téma leírása:
The vascular endothelium serves as a selective barrier to fluid and solute flux across the blood vessel walls. Dephosphorylation of phosphoproteins by phospho-Ser/Thr-specific protein phosphatases is crucial in the regulation of endothelial barrier function. Our goal is to learn about the regulatory role of protein phosphatase (PP) 1 on endothelial barrier function in the lung and in the brain, through its regulatory/interacting protein partners. TIMAP (TGFβ-inhibited membrane associated protein), a member of the MYPT family of PP1 targeting subunits, is indeed a regulatory subunit of PP1. While MYPT1 has been extensively studied, much less is known about TIMAP. TGF-β represses TIMAP in endothelial cells, but TGF-β was also shown to be upregulated in the brain in multiple sclerosis, Alzheimer’s disease, stroke, tumors, or trauma. Therefore, our research will be focused on the hypothesis that TIMAP, as a regulatory subunit of PP1, is an active participant in establishment/maintenance of the blood brain barrier. Besides, we aim to widen our knowledge on new protein partners of TIMAP in EC.
előírt nyelvtudás: angol középfok felvehető hallgatók száma: 1
Jelentkezési határidő: 2016-11-01
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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