Thesis supervisor: István Krizbai
co-supervisor: Imola Wilhelm
Location of studies (in Hungarian): MTA Szegedi Biológiai Kutatóközpont, Biofizikai Intézet Abbreviation of location of studies: SzBK
Description of the research topic:
By forming a single cell layer lining the blood vessels of the brain, cerebral endothelial cells (CECs) – coming in close contact with pericytes and astrocytes – constitute the principal components of the blood-brain barrier (BBB). Tight junctions (TJs) and adherens junctions (AJs) play a key role in the maintenance of the barrier function. Despite considerable experimental efforts, the molecular organization and regulation of cerebral interendothelial junctions is less well understood. Our project is focused on the role of interendothelial junctions under pathological conditions like inflammatory stimuli. Our aim is to understand the yet unexplored roles of the BBB in neuroimmune and neuroinflammatory processes. The experiments will be carried out on in vitro and in vivo models. Using different molecular, biochemical and immunofluorescent techniques we will investigate the expression, localization, interaction and posttranslational modifications of the junctional proteins (occludin, claudins, ZO-1, ZO-2, cadherins, catenins) in CECs. We will also elucidate the expression and function of pattern recognition receptors in the cells of the BBB.
Number of students who can be accepted: 1
Deadline for application: 2016-09-30
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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