PACAP was first isolated from the hypothalamus, however, it was later shown to be distributed not only in the entire brain but also in peripheral organs. High concentrations of PACAP can be found in the urogenital system, in endocrine glands, in the gastrointestinal and respiratory systems. PACAP plays regulatory roles in reproductive functions, influences gastrointestinal motility and secretion and peripheral inflammatory processes. A lot of biological effects are still not described, however. We are investigating the roles of PACAP in neurogenic inflammation, pain transmission, secretory processes, kidney physiology, behavioral processes and memory. All these functional studies also involve the use of PACAP deficient (KO) mice, to elucidate the endogenous effects of the peptide. We also investigate the occurrence of the peptide in biological samples and fluids, which can pave the path for future diagnostic use. We standardize the measurements of PACAP in human plasma and other fluids, using radioimmunoassay and mass spectrometry. Comparing normal, healthy values and samples obtained from patients will hopefully help us to elaborate a method to use PACAP as a biomarker.
felvehető hallgatók száma: 1
Jelentkezési határidő: 2024-05-16
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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