témavezető: Dóczi Tamás
helyszín (magyar oldal): PTE ÁOK Pécs, Szigeti u. 12. helyszín rövidítés: ÁOK
A kutatási téma leírása:
Monroe described the concept on the volume-regulation of intracranial compartments in 1824, and Kellie has tested it in clinical settings in 1873. The pressure-volume relationship between ICP, volume of CSF, blood, and brain tissue, and cerebral perfusion pressure (CPP) is known as the Monro-Kellie doctrine or the Monro-Kellie hypothesis. The original hypothesis states that the cranial compartment is incompressible, and the volume inside the cranium is a fixed volume. The cranium and its constituents (blood, CSF, and brain tissue) create a state of volume equilibrium, such that any increase in volume of one of the cranial constituents must be compensated by a decrease in volume of another as stated first by Burrows in 1846 and employed in clinical practice by Cushing since 1925. The principal buffers for increased volumes include both CSF and, to a lesser extent, blood volume. These buffers respond to increases in volume of the remaining intracranial constituents. In the initial era of modern neurosurgery macrosurgical techniques were employed. It was served by indirect diagnostics such as ventriculography, pneumo-encephalography and efficiency was measured by means of mortality rates. Micro-neurosurgery is the gold standard of neurosurgery of our days. It is served by direct diagnostic methods, such as CT, MRI and DSA. Microsurgical technique is based on 5-15 X magnification of the operation field described by microtopography. Surgical target is approached via non-invasive pathways, i.e. the CSF spaces. Operating microscope and specialized micro-instruments have been developed, and therapeutical efficiency has been measured by morbidity data. We have now the “digital era”: neuronavigation (like a GPS system), “key-hole” minimal-invasive craniotomy and techniques, functional neurosurgery, endovascular neurosurgery by means of DSA, stereotactic fractionated radiotherapy or radiosurgery. The program is presenting all of the physiological, anatomical, pathological, biochemical and molecular biological data necessary to the understanding of modern digital neurosurgery.
felvehető hallgatók száma: 1
Jelentkezési határidő: 2024-05-16
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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