It is known that during diseases or various pathological conditions, the functioning of individual organs can change. We have relatively little data on what changes can occur in the absorption and elimination of pharmacones in cases when conditions other than physiological appear, for example, in the case of chronic diseases. In the framework of this research, the effect of hyperglycaemia, one of the very important and widespread pathological conditions, is examined on the hepatic and the intestinal metabolism, and excretion of drugs. In animal studies, experimental diabetes is induced by streptozotocin, and its effect on absorption and elimination activity in the experimental animals is studied by chromatographic analysis of small intestine perfuzate and bile samples. With such experiments, we can also answer the question of whether one of our organs might be able to compensate for the reduced or lost elimination function of another organ.
felvehető hallgatók száma: 1
Jelentkezési határidő: 2022-05-20
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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