témavezető: Hegyi Péter
helyszín (magyar oldal): PTE ÁOK Pécs, Szigeti u. 12. helyszín rövidítés: ÁOK
A kutatási téma leírása:
Celiac disease (CD) is a systemic immune-mediated disorder. In addition to the genetic vulnerability (HLA-DQ2 or DQ8 alleles), the consumption of gluten-containing cereals (that is, wheat, barley, and rye) play a crucial role in the disease pathogenesis. The clinical phenotype of CD varies: intestinal (e.g., diarrhea and abdominal pain) and extraintestinal symptoms (e.g., anemia, osteoporosis, dermatitis herpetiformis, autoimmune diseases, and malignancies) can develop. The only feasible therapeutic option is the lifelong strict gluten-free diet (GFD). The introduction of the GFD is usually followed by a quick and complete remission of the symptoms: the quality of life improves, the complication rate and the mortality drop. Tools for monitoring dietary adherence are limited. The former gold standard was the achievement of small intestinal mucosal recovery, but recent guidelines do not recommend the invasive control biopsy in asymptomatic patients. Celiac-specific serology, i.e., the level of serum tissue-transglutaminase antibody (tTG-IgA/G) in adults, can refer to major dietary transgressions but not to the occasional intake of trace amounts of gluten. Today, dietary questionnaires, collecting self-reported data of which objective interpretation is difficult to execute, are used in the first line. The aim of this project is to examine newly emerging methods and to make a comparison between these and the earlier gold standards to facilitate stricter follow-up of CD patients. In the long run, our results might contribute to the measurement of the effects of newly emerging celiac-specific drugs (e.g., zonulin inhibitors).
felvehető hallgatók száma: 1
Jelentkezési határidő: 2022-05-20
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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