Age-related regulatory alterations may be assumed in the background of middle-aged obesity and aging anorexia since they also appear in other mammals. Our previous studies described such regulatory alterations of the central catabolic melanocortin system: a weak catabolic responsiveness to alpha-melanocyte stimulating hormone in middle-aged and a strong one in old age-groups. Corticotropin releasing factor (CRF) and urocortins are important catabolic peptide mediators downstream to the melanocortins. Their effects are mediated by CRF1 and CRF2 receptors. In the PhD program we aim to investigate the age- and nutritional state-associated alterations in the central corticotropin system (and those of its receptors). Animal experiments will carried out in different age-groups (from juvenile to old) of laboratory rodents. Regarding nutritional state, we establish ad libitum fed, diet-induced obese and calorie-restricted groups withing the age-groups. During the analysis of central acute and chronic corticotropin responsiveness, food intake is to be recorded in an automated FeedScale system, circadian rhythm of core temperature, heart rate, spontaneous locomotor activity in a biotelemetric system (MiniMitter, Respironics). These measurements will be complemented by the registration of oxygen consumption, core and tail skin temperature (the latter indicates heat loss) in an Oxymax system (Columbus) for indirect calorimetry.
felvehető hallgatók száma: 1
Jelentkezési határidő: 2022-05-20
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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