Intrauterine and early perinatal development (with special emphasis on the nutritional status of the mother and offspring and such environmental factors as physical exercise) exert a significant influence on regulatory systems of energy homeostasis (hormonal imprinting). Such alterations in the peripheral and central mediator systems may contribute to the development of early onset (childhood) obesity and the appearance of severe forms of metabolic syndrome later in life. In the PhD program in addition to the effects of malnutrition and excess caloric intake of the mother (intrauterine) and offspring (perinatal), the influence of physical activity of young individuals and those of perinatal capsaicin desensitization (to determine the role of capsaicin-sensitive neural afferents) on the development and abnormal alterations of the peripheral and central regulatory systems of energy balance will be analyzed. To achieve these objectives, the body weight, food intake development of rats will be followed continuously. To test the development and alterations of the regulatory systems, responsiveness of central catabolic (e.g. melanocortin, corticotropin) and anabolic (e.g. neuropeptide Y, agouti related peptide, orexin) systems will be tested in different age-groups of rats. Food intake is to be recorded in an automated FeedScale system, circadian rhythm of core temperature, heart rate, spontaneous locomotor activity in a biotelemetric (MiniMitter system). These measurements will be complemented by the registration of oxygen consumption, core and tail skin temperature (the latter indicates heat loss) in an Oxymax system for indirect calorimetry.
felvehető hallgatók száma: 1
Jelentkezési határidő: 2022-05-20
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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