The controlled degradation of proteins through the ubiquitin-proteasome system is one of the main mechanisms that regulates protein abundance. This regulatory mechanism is essential in various biological processes that requires the rapid elimination of proteins that are no longer needed, most notably in cell-cycle regulation, stress response or various signaling processes. The key enzymes of targeted degradation are the E3 ligases, which mediate the attachment of ubiquitin to substrates by recognizing specific functional elements in their target proteins, called degrons. Most degrons are short linear motifs located within intrinsically disordered segments that can be easily modulated depending on various cellular cues. The growing number of known degron motifs clearly indicate their biological importance and their relevance in various diseases. However, in general degron motifs in proteins are still largely unexplored. The aim of the project is the identification of novel degron motifs for which both computational and experimental methods can be used.
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