The structural states of proteins include ordered globular domains as well as intrinsically disordered protein regions that exist as highly flexible conformational ensembles in isolation. Various computational tools have been developed to discriminate ordered and disordered segments based on the amino acid sequence. However, properties of IDRs can also depend on various conditions, including binding to globular protein partners or environmental factors. These context dependent disordered cases provide further challenges for the computational characterization of disordered segments. The aim of the proposed project us to use various bioinformatic tools and develop dedicated prediction methods to characterize various types of context-dependent disordered proteins and their relationship to function.
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