témavezető: Bálint Bálint László
helyszín (magyar oldal): University of Debrecen helyszín rövidítés: DE ÁO
A kutatási téma leírása:
Cancer progression becomes feasible due to the evolution of cancer cells and the ability to hide themselves from the immune system. This capacity has been considered to be influenced by epigenetic mechanisms and therefore could be reversed by epigenetic agents. With the development of programmed cell death receptor antagonist based immunotherapies the triggering of programmed cell death of cancer cells became a feasible strategy. We plan to investigate the components of PD1-PDL1 axis in normal and breast cancer cell modells and the influence of epigenetic modulators in reactivation of the endogenous cancer defeat mechanisms.
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