témavezető: Nagy László
helyszín (magyar oldal): University of Debrecen helyszín rövidítés: DEÁOK
A kutatási téma leírása:
The proposed research is the logical continuation of the work described in our publication (Daniel et al 2014). We are proposing to systematically analyze the interaction of key transcriptional regulators of macrophage polarization and angiogenic activity. We propose two specific aims. In aim 1 we will use state of the art epigenomic methods to map the contribution and genome-wide interaction, enhancer selection of a set of transcription factors (PPARg, STAT6, EGR2). In the second aim we will study the regulation of twokey angiogenic genes VEGFa and HBEGF to understand how macrophage polarization and gene expression leads to an angiogenic phenotype of the cell.