témavezető: Schlett Katalin
helyszín (magyar oldal): Eötvös Loránd University, Dept. Physiology and Neurobiology, Neuronal Cell Biology Research Group helyszín rövidítés: ELTE
A kutatási téma leírása:
Learning and forgetting are indispensable for life and depend on the strengthening or debilitation of synaptic connections, respectively. AMPA ionotropic glutamate receptors (AMPARs) are key regulators of synaptic activity, with strictly controlled amounts within the synapses. Recent data support that improper regulation of AMPARs lead to the development of psychiatric symptoms, including Post-Traumatic Stress Disorder (PTSD). GAP proteins inactivate small GTPases which is counteracted by GEF proteins that promote GTPase activity. The spatio-temporal regulation of GAPs and GEFs thus determines the local activity of small GTPases. The amount and rapid turnover of AMPARs at the postsynaptic site are regulated by specific Rab GTPases, known to direct the recycling (Rab11) or endocytosis (Rab5) of AMPARs. Based on our recent publications (see Sziber et al., 2017; Hausser and Schlett, 2017), we propose that selective modulation of Rab5 and Rab11 will have a direct impact on the removal of AMPARs from synapses, which could block the onset of PTSD. Thus, we aim to characterize the Rab-dependent regulation of AMPAR turnover and plasticity in living neurons.
előírt nyelvtudás: English B2 további elvárások: MSc thesis in neuroscience, cell biology or molecular biology; previous experience with microscopy or mammalian cell culture and animal handling is an advantage
Jelentkezési határidő: 2018-05-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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