témavezető: Huszthy Péter
helyszín (magyar oldal): BME Szerves Kémia és Technológia Tanszék helyszín rövidítés: BME
A kutatási téma leírása:
By the action of molecular recognition a molecule called the "host" is able to pull out another molecule called a "guest" out of the mixture of molecules selectively, and they form a complex. This host–guest complex is held together by non-covalent or weak intermolecular forces. Enantiomeric recognition as a special case of molecular recognition involves the discrimination between the enantiomers of a chiral guest by a chiral host. Molecular recognition, which is a generally occurring phenomenon in living organisms, can also be engineered into relatively simple synthetic hosts such as crown ethers, which can mimic the behaviour of large biomolecules and are able to act as effective sensor and selector molecules and also as catalysts. The PhD student is required to work on the synthesis, molecular recognition and use of new crown ether derivatives. Enantiopure crown ether derivatives are planned to be immobilized to solid supports, such as silica gel or polymer resin, which can be used then as chiral stationary phases (CSPs) and/or catalysts in asymmetric syntheses. Optically active crown ether-based carriers, fluorescent sensors and solid-supported organocatalysts are also intended to be prepared and studied.