témavezető: Somsák László
helyszín (magyar oldal): DE TTKSzerves Kémiai Tanszék E 422 helyszín rövidítés: E 422
A kutatási téma leírása:
The C-glycosyl compounds exhibit a wide range of interesting biological effects, play important roles in the formation of hydrolitically stable carbohydrate derivatives as glycomimetics, and are the active ingredients of several recent antidiabetic medications. C-Glycosyl heterocycles with five-membered rings have extensively been studied as to their syntheses and biological activities. On the other hand, similar derivatives of six-membered heterocycles and especially their C-glycopyranosyl counterparts are very scarcely known in the literature among others due to the lack of suitable precursors.
This PhD project has a dual aim: a) based on precursors synthesized recently in our group, elaboration of the synthesis of nitrogen heterocycles with 1-4 heteroatoms; b) study of the possibilities for interconversion of the a forementioned heterocycles.
Under aim a) imidate, amidine and amidrazone type derivatives of anhydro-aldonic acids will be investigated to reveal the applicable protecting groups in their transformations to the target heterocycles, while under aim b) the inverse-electron demand Diels-Alder reactions of triazines and tetrazines towards pyridines and pyridazines will be studied.
előírt nyelvtudás: angol felvehető hallgatók száma: 2
Jelentkezési határidő: 2018-05-15
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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