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Jeney Viktória
Effect of iron on osteogenic differentiation

TÉMAKIÍRÁS

Intézmény: Debreceni Egyetem
elméleti orvostudományok
Molekuláris sejt- és immunbiológia Doktori Iskola

témavezető: Jeney Viktória
helyszín (magyar oldal): Debreceni Egyetem, Általános Orvostudományi Kar
helyszín rövidítés: DEÁOK


A kutatási téma leírása:

Osteogenic differentiation is a key event in bone and tooth development. Excess iron has a detrimental role in bone physiology resulting osteopenia, osteoporosis and bone fractures in patients with different forms of iron overload diseases. Recently we investigated the osteogenic differentiation potential of mesenchymal stem cells (MSCs), and found that iron inhibited osteogenic differentiation of MSCs. We lack information about whether patients with iron overload diseases have abnormalities of tooth development.
Dental pulp cells are stem cells, with a strong potential towards osteogenic differentiation, having an important role in tooth development and proper extracellular matrix formation. Under this project we will investigate the effect of excess iron on osteogenic differentiation of dental pulp cells. We will investigate how modulation of iron homeostasis influences osteogenic differentiation and extracellular matrix mineralization of dental pulp cells. We will determine mRNA and protein expressions of certain osteoblast-specific markers, such as RUNX2, SOX9, alkaline phosphatase, osteocalcin, etc. We will also measure matrix mineralization with different technics. Numerous signaling mechanisms are involved in osteogenic differentiation of MSCs. We will investigate whether the same mechanisms are implicated in osteogenic differentiation of dental pulp cells and whether excess of iron impair those signaling pathways.


Jelentkezési határidő: 2018-05-15


2018. V. 04.
ODT ülés
Az ODT következő ülésére 2018. május 25-én 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).

 
Minden jog fenntartva © 2007, Országos Doktori Tanács - a doktori adatbázis nyilvántartási száma az adatvédelmi biztosnál: 02003/0001. Program verzió: 2.2358 ( 2017. X. 31. )