témavezető: Péczely László Zoltán
helyszín (magyar oldal): PTE ÁOK Pécs, Szigeti u. 12. helyszín rövidítés: ÁOK
A kutatási téma leírása:
The aim of our research is to clarify the role of limbic structures and the innervating mesolimbic dopaminergic system in learning processes. The structures investigated in our experiments are the prefrontal cortex, hippocampus, nucleus accumbens, amygdala and the ventral pallidum, as well as the ventral tegmental area providing dopaminergic innervation of these structures. We have multilevel approach: on the one hand, the effects of dopamine receptor activation or inhibition in various brain regions will be investigated, on the other hand, the interaction of mesolimbic dopaminergic system with other neurotransmitter systems, as well as the interaction among the different brain regions will be studied. In our experiments, combining electrophysiological and neuropharmacological techniques in anaesthetised, as well as in awake freely moving rats, the effects of various neuropharmacons, primarily dopamine agonists and antagonists are investigated in the aforementioned brain areas, applying various learning-behavioural paradigms. These latter include the Morris water maze test used to examine spatial learning, the various avoidance paradigms to test punishment learning and the place preference paradigm, which is applied to investigate the potential rewarding or punishing effect of the administered drugs, etc. This study will be accomplished with male Wistar rats, the cannulae and the electrodes will be implanted to the target area by means of the stereotaxic technique. In this research program, the adequate combination and mathematical analysis of behavioural and electrophysiological data are in the focus of our attention allowing deeper interpretation of the experimental results. Findings of these experiments may contribute to the better understanding of the exact role of D2 dopamine receptor antagonists used in antipsychotic medication, therefore, the results may have therapeutical relevance.
felvehető hallgatók száma: 1
Jelentkezési határidő: 2018-05-18
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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