The role of tachykinins and the neuropeptide interactions in the mechanisms of learning, reinforcement, memory and in the regulation of addictive behavior
The limbic system has a substantial role in the control of learning and memory processes, in motivation and reinforcement, and also in emotional processes. In the regulation of these mechanisms the dopaminergic (DA) system is essentially involved. The main goal of the project is, however, to unravel the functional role of DA - neuropeptide interactions and the investigation of the modulatory effects of neuropeptides. The role of substance P (SP) is confirmed in learning and memory processes, in the positive reinforcement, as well as in fear and anxiety. Electrophysiological, neurochemical and behavioral methods will be applied to investigate the effects of tachykinins, included SP, and its antagonists in the aforementioned processes, on the function of the limbic neurons and on the DA interactions in the terminal fields of the mesolimbic DA system. The effects of different doses of tachykinins and their antagonists will be investigated in behavioral tests (open field, rotarod, place preference, elevated maze, Morris water maze tests), and in electrophysiological experiments (single unit, multibarrel technique). Immunohistological examinations will be performed to detect SP immunoreactivity in limbic structures. After immunological lesions we will examine the behavior of Wistar rats in the former tests. Our results may contribute to unravel the still unknown peptidergic processes of learning, reinforcement and drug addiction.
felvehető hallgatók száma: 1
Jelentkezési határidő: 2018-05-18
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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