témavezető: Hamari Zsuzsanna
helyszín (magyar oldal): University of Szeged, Faculty of Sciences, Department of Microbiology - SZTE TTIK Mikrobiológiai Tanszék helyszín rövidítés: SZTE
A kutatási téma leírása:
The High Mobility Group –box (HMGB) proteins are non-histone chromatin associated proteins, which promote the stabile binding of chromatin remodeling complexes and other chromatin associated factors to the chromatin due to their ability to bind the DNA and establish interactions with the chromatin modulating factors. We had identified three HMGB proteins in Aspergillus nidulans. We had described the physiological role of one of these proteins, HmbB (Karácsony és mtsai 2014, 2015). We aim to shed light on the biological problems raised by the study of HmbB (molecular mechanism of the regulation of the sterigmatocystin production by HmbB) and reveal the physiological role of the other two HMGB proteins, HmbA and HmbC.
Karácsony Z, Gácser A, Vágvölgyi C, Scazzocchio C, Hamari Z. (2014) A dually located multi-HMG-box protein of Aspergillus nidulans has a crucial role in conidial and ascospore germination. Mol Microbiol. 2014 Oct;94(2):383-402.
Karácsony Z, Gácser A, Vágvölgyi C, Hamari Z. (2015) Further characterisation of the role of the mitochondrial HMG-Box protein in the intracellular redox environment of Aspergillus nidulans. Microbiology. 2015 Oct;161(10):1897-908
előírt nyelvtudás: English további elvárások: basic microbiological and molecular biological skills
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