témavezető: Wittmann István
helyszín (magyar oldal): PTE ÁOK Pécs, Szigeti u. 12. helyszín rövidítés: ÁOK
A kutatási téma leírása:
As described in our patent ’Hormone resistance’, it has been discovered that accumulation of hydroxyl free radical products takes place in the blood vessel wall exposed to oxidative stress. These results are planned to be extended: we plan to investigate the insulin- and erythropoietin resistance developed in fat cells and the acetyl-choline resistance developed in the vessels due to the accumulation of ortho- and meta-tyrosine. We further plan to study the accumulation of abnormal tyrosine isoforms and their effects in renal failure.